Grape Seed Extract Constituents Show Powerful Benefits
For the doctors of NutriPlex Formulas.
This information is provided so our doctors can have a quick overview of the benefits of Grape Seed Extract.
Grape Seed Extract (contained in NutriPlex Formulas’ SuperGreens PhytoFood) is one of the greatest “superfood” finds of the era. There are many health benefits, and two of its most promising constituents are resveratrol and proanthocyanidins.
The information below can be found on the website of pdrhealth.com...
The amount of resveratrol (trans-resveratrol) in peanuts ranges from 0.02 to 1.79 micrograms per gram. Red wine contains from 0.6 to 0.8 micrograms per milliliter, and fresh grape skin, approximately 50 to 100 micrograms per gram. A glass of red wine delivers on the average, between 600 to 700 micrograms of resveratrol.
Resveratrol has demonstrated inhibition of growth of several cancer cell lines and tumors, suggesting that it has an inhibitory effect on cancer promotion/progression. It has been found to inhibit ribonucleotide reductase, DNA polymerase, the transcription of COX-2 in human mammary epithelial cells and the activity of ornithine decarboxylase. Ornithine decarboxylase is a key enzyme of polyamine biosynthesis, which is enhanced in tumor growth.
Resveratrol has also been found to induce phase II metabolizing enzymes which are involved in the detoxification of carcinogens, to upregulate apoptosis, to inhibit the progression of cancer by inducing cell differentiation and to inhibit protein kinase D and possibly protein kinase C.
In a number of mostly in vitro studies, resveratrol has demonstrated an ability to inhibit tumor initiation, promotion and progression. Some of its antiproliferative activity is attributed to its observed ability to inhibit ribonucleotide reductase and DNA synthesis in mammalian cells. It has been shown to induce apoptotic cell death in human leukemia cell lines, as well as in some breast carcinoma cells.
Its antiestrogenic activity is also believed to play a role in its inhibition of human breast cancer cells in vitro. A partial estrogen-receptor agonist itself, resveratrol is believed by some researchers to be an estrogen-receptor antagonist in the presence of estrogen, resulting in breast cancer inhibition.
Finally, resveratrol has recently shown activity against herpes simplex virus types 1 and 2 in a dose-dependent manner. It appears to disrupt a critical early event in the viral reproduction cycle.
Grape seeds offer a wide variety of antioxidant, anti-cancer and other benefits, according to the web site PDRHealth.com. A type of mixed flavonoid - proanthocyanidins - extracted from grape seeds are the essential ingredient.
• The proanthocyanidins are what's important here: They have been shown to hold antioxidant properties.
• In laboratory tests, grape seeds have been considered to have possible anti-inflammatory, anti-cancer and anti-atherogenic properties.
• Lab tests suggest that the anti-cancer properties include cardioprotective (heart) properties, hepatoprotective (blood / liver) properties and capillary protective properties. Grape seeds also have, through in vitro tests, been observed to help fight lung, breast and stomach cancers.
• Anecdotal evidence suggests that they also are useful for treating varicose veins, arthritis and some allergies.
• In other in vitro tests, the grape seeds have been linked with helping the vascular system.
Antitumor-promoting activity, described as highly significant, has been observed in animals treated with topical grape seed proanthocyanidins. Skin tumor incidence, multiplicity and volume were all significantly inhibited. These effects were attributed to inhibition of epidermal lipid peroxidation. Higher doses resulted in greater degrees of cancer inhibition.
sources:
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/gra_0129.shtml
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/res_0224.shtml
This information is provided so our doctors can have a quick overview of the benefits of Grape Seed Extract.
Grape Seed Extract (contained in NutriPlex Formulas’ SuperGreens PhytoFood) is one of the greatest “superfood” finds of the era. There are many health benefits, and two of its most promising constituents are resveratrol and proanthocyanidins.
The information below can be found on the website of pdrhealth.com...
The amount of resveratrol (trans-resveratrol) in peanuts ranges from 0.02 to 1.79 micrograms per gram. Red wine contains from 0.6 to 0.8 micrograms per milliliter, and fresh grape skin, approximately 50 to 100 micrograms per gram. A glass of red wine delivers on the average, between 600 to 700 micrograms of resveratrol.
Resveratrol has demonstrated inhibition of growth of several cancer cell lines and tumors, suggesting that it has an inhibitory effect on cancer promotion/progression. It has been found to inhibit ribonucleotide reductase, DNA polymerase, the transcription of COX-2 in human mammary epithelial cells and the activity of ornithine decarboxylase. Ornithine decarboxylase is a key enzyme of polyamine biosynthesis, which is enhanced in tumor growth.
Resveratrol has also been found to induce phase II metabolizing enzymes which are involved in the detoxification of carcinogens, to upregulate apoptosis, to inhibit the progression of cancer by inducing cell differentiation and to inhibit protein kinase D and possibly protein kinase C.
In a number of mostly in vitro studies, resveratrol has demonstrated an ability to inhibit tumor initiation, promotion and progression. Some of its antiproliferative activity is attributed to its observed ability to inhibit ribonucleotide reductase and DNA synthesis in mammalian cells. It has been shown to induce apoptotic cell death in human leukemia cell lines, as well as in some breast carcinoma cells.
Its antiestrogenic activity is also believed to play a role in its inhibition of human breast cancer cells in vitro. A partial estrogen-receptor agonist itself, resveratrol is believed by some researchers to be an estrogen-receptor antagonist in the presence of estrogen, resulting in breast cancer inhibition.
Finally, resveratrol has recently shown activity against herpes simplex virus types 1 and 2 in a dose-dependent manner. It appears to disrupt a critical early event in the viral reproduction cycle.
Grape seeds offer a wide variety of antioxidant, anti-cancer and other benefits, according to the web site PDRHealth.com. A type of mixed flavonoid - proanthocyanidins - extracted from grape seeds are the essential ingredient.
• The proanthocyanidins are what's important here: They have been shown to hold antioxidant properties.
• In laboratory tests, grape seeds have been considered to have possible anti-inflammatory, anti-cancer and anti-atherogenic properties.
• Lab tests suggest that the anti-cancer properties include cardioprotective (heart) properties, hepatoprotective (blood / liver) properties and capillary protective properties. Grape seeds also have, through in vitro tests, been observed to help fight lung, breast and stomach cancers.
• Anecdotal evidence suggests that they also are useful for treating varicose veins, arthritis and some allergies.
• In other in vitro tests, the grape seeds have been linked with helping the vascular system.
Antitumor-promoting activity, described as highly significant, has been observed in animals treated with topical grape seed proanthocyanidins. Skin tumor incidence, multiplicity and volume were all significantly inhibited. These effects were attributed to inhibition of epidermal lipid peroxidation. Higher doses resulted in greater degrees of cancer inhibition.
sources:
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/gra_0129.shtml
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/res_0224.shtml
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